Travis Hoppe, Robert Best
Goal: Develop a model for IDP binding interactions.
MF Energy distributions: Physically reasonable
Pairwise decomposition of protein complex energy; Binding affinity
Contact matrix is not symmetric
Specificity score: Define "decoys" as weakly bound
structures in protein network.
What's next? Add structure to mean field calculations.
Lattices may be optimal for IDP's, they can reproduce native-energies but quickly sample extended conformational space.
Laboratory of Chemical Physics